Biologics

Spinal Implants

Clinical Evidence

Advancing Care Through Clinical Evidence

Scientific evidence plays an important role in helping surgeons evaluate biologic technologies and make informed treatment decisions. Explore published clinical papers, peer-reviewed research, case studies, and technical resources supporting Xtant Medical’s regenerative portfolio.
As new evidence continues to emerge, we remain committed to expanding the body of scientific literature that supports our technologies and the surgeons who use them.
Browse the publications below by product or specialty.
Clinical Certifications
Reconstruction of Complex Osteochondral Lesions of the Talus with Cylindrical Sponge Allograft and Particulate Juvenile Cartilage Graft
A Retrospective Analysis Evaluating Allogeneic Cancellous Bone Sponge for Foot and Ankle Arthrodesis
Biologic Augmentation of Foot and Ankle Arthrodeses with an Allogeneic Cancellous Sponge
The Role of Demineralized Allograft Subchondral Bone in the Treatment of Talar Cystic OCD Lesions That Have Failed Microfracture

Transforaminal Lumbar Interbody Fusion Rates Using a Novel Titanium Implant and Demineralized Cancellous Allograft Bone Sponge

Rationale, Characteristics, and Clinical Performance of the OsteoSponge®
Evaluation of a New Formulation of Demineralized Bone Matrix Putty in a Rabbit Posterolateral Spinal Fusion Model
The Effect of Temperature Exposure During Shipment on a Commercially Available Demineralized Bone Matrix Putty

High Lumbar Noninstrumented Fusion Rates Using Lamina Autograft and NanOss/BMA

High Posterior Cervical Fusion Rates with Iliac Autograft and NanOss/BMA

Use of Nanocrystalline Hydroxyapatite With Autologous BMA and Local Bone

Preliminary Study Showing Safety/Efficacy of NanoSS Bioactive Versus Vitoss as Bone Graft Expanders for Lumbar Noninstrumented Fusions
Preliminary Documentation of the Comparable Efficacy of Vitoss Versus NanOss Bioactive as Bone Graft Expanders for Posterior Cervical Fusion
Prospective, Multicenter, Randomized, Controlled Trial Evaluating the Performance of a Novel Combination Powder vs Hemostatic Matrix in Cardiothoracic Operations
Application Techniques of a Novel Hemostat in Cardiac Operations
An Investigational Time-Course Study Using an In Vivo Ovine Laminectomy Model for the Neurohistopathological Evaluation of Hemostatic Agents

The Use of Hemostatic Agents to Decrease Bleeding Complications in General Plastic Surgery Procedures

The Use of Hemostatic Agents to Decrease Drain Time in Breast Cancer Surgery Procedures

Bleazey & Brigido – Reconstruction of Complex Osteochondral Lesions of the Talus

Brigido – Allogeneic Cancellous Bone Sponge for Foot and Ankle Arthrodesis

Protzman – Biologic Augmentation of Foot and Ankle Arthrodeses

Galli – Demineralized Allograft Subchondral Bone in Talar OCD Lesions

Girasole – TLIF Using Titanium Implant and OsteoSponge

Yoon – DBM Sponges in Posterolateral Lumbar Spine Fusion

Kiely – New Formulation of DBM Putty in Rabbit Fusion Model

High lumbar noninstrumented fusion rates using lamina autograft and NanOss/BMA

High posterior cervical fusion rates with iliac autograft and NanOss/BMA

Use of Nanocrystalline Hydroxyapatite With Autologous BMA and Local Bone

NanOss Bioactive versus Vitoss for Lumbar Fusion

Vitoss versus NanOss for Posterior Cervical Fusion

An investigational time-course study using an in vivo ovine laminectomy model for the neurohistopathological evaluation of hemostatic agents

Miller – Rationale, Characteristics and Clinical Performance of OsteoSponge

Prospective, multicenter, randomized, controlled trial evaluating the performance of a novel combination powder vs hemostatic matrix in cardiothoracic operations

Application techniques of a novel hemostat in cardiac operations: HEMOBLAST

Chatterjee – American Surgeon

Olano – The Use of Hemostatic Agents to Decrease Drain Time in Breast Cancer Surgery Procedures

Schallenberger – Temperature Exposure on DBM Putty